Browsing by Author "Chacha, Musa"
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Item A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts(Taylor & Francis) Christopher, R.; Nyandoro, Stephen S.; Chacha, Musa; de Koning, C. B.Item Activity of sterols isolated from the leaves of commiphora swynnertonii (Burtt) against some nosocomial infectious bacteria(The Journal of Phytopharmacology, 2022-09-04) Credo, David; Mabiki, Faith P.; Machumi, Francis; Chacha, Musa; Cornett, ClausCommiphora swynnertonii (Burtt) is traditionally used for medicinal purposes both in humans and animals in Tanzania. Previously, its leaves extract has been demonstrated antibacterial activity. However, there is limited information on identification of pure compounds responsible for its observed antibacterial activity. Therefore, this study was conducted to isolate and evaluate antibacterial activity of pure compounds isolated from its leaves extract. Colum chromatographic separation of its dichloromethane leaves extract afforded the isolation of two sterols namely, Cholest-7-en-3β-ol (1) and β-sitosterol (2). Their structures were deduced by using NMR data experimentally obtained and comparison with spectral data available in literatures. The sterols were evaluated for activity against four nosocomial infectious bacteria namely; Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa to determine Minimum Inhibitory Concentrations (MIC) by broth microdilution method. Cholest-7-en-3β-ol (1) demonstrated strong activity against S. aureus (MIC= 0.5 mg/ml) and weak activities (MIC >2mg/ml) against other bacteria. β-sitosterol (2) exhibited weak activities (MIC >2mg/ml) against all tested bacteria. Therefore, presence of antibacterial active compound(s) such as Cholest-7-en-3β-ol (1) among others in the leaves of C. swynnertonii can justify its earlier reported antibacterial activity and further confirms the claimed traditional uses of this plant in the treatment of bacterial infections.Item Acute and Subacute Oral Toxicity Evaluation of Commiphora Campestris Methanolic Stem Bark Extract (CASBMCE) In Mice and Rats(Juniper Publishers) Chacha, Musa; Nyunza, Furaha; Makule, EdnaItem Acute oral toxicity study of Mystroxylon aethiopicum root bark aqueous extract in albino mice(Journal of Medicinal Plants Research) Kilonzo, Mhuji; Ndakidemi, Patrick A.; Chacha, MusaItem Adequacy of micronutrient fortification in the mandatory fortified food vehicles in Tanzana(Emerald Publishing Limited) Kiwango, Flavia Andrew; Chacha, Musa; Raymond, JofreyItem Allelopathic Effects of Sphaeranthus suaveolens on Seed Germination and Seedling Growth of Phaseolus vulgaris and Oryza sativa(Hindawi) Laizer, Hudson C.; Chacha, Musa; Ndakidemi, Patrick A.Item Analysis of phytochemical composition of Bersama abyssinica by gas chromatography – mass spectrometry(Journal of Pharmacognosy and Phytochemistry) Zekeya, Never; Chacha, Musa; Shahada, Francis; Kidukuli, AbdulItem Antibacterial and antifungal activities of selected wild mushrooms from Southern Highlands of Tanzania(American Journal of Research Communication) Chelela, Baraka; Chacha, Musa; Matemu, AthanasiaItem Antifungal Effects against Phaeoisariopsis personata under Greenhouse Conditions and Phytochemical Analysis of Jatropha curcas Leaf Extracts(International Journal of Agriculture and Biology) Francis, Magreth; Chacha, Musa; Ndakidemi, Patrick; Mbega, ErnestItem Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice(Dovepress) Mzena, Theopista; Swai, Hulda; Chacha, MusaItem Antimicrobial activities of against selected pathogenic fungi and bacteria strains.(Taylor & Francis Online) Chacha, Musa; Mlozi, Stephano; Mmongoyo, JumaItem Antimicrobial and Cytotoxicity Activity of Clausena anisata, Acokanthera shemperii and Olea europaea Growing in Tanzania(European Journal of Medicinal Plants) Makirita, Winisia E.; Chauka, Leonard J.; Chacha, MusaItem Antimicrobial and Cytotoxicity Activity of Clausena Anisata, Acokanthera Shemperii and Olea Europaea Growing in TanzaniaMakirita, Winisia E.; Chauka, Leonard J.; Chacha, MusaItem Bioaccumulation and distribution pattern of heavy metals in aquaculture systems found in Arusha and Morogoro regions of Tanzania(Taylor & Francis Group) Nyamete, Frida; Chacha, Musa; Msagati, Titus; Raymond, JofreyItem Context-specific optimal dietary guidelines for managing cancer for hospitalized patients in Tanzania(Emerald Publishing Limited) Kisighii, Happyness; Raymond, Jofrey; Chacha, MusaItem Development of a Natural Product Rich in Bioavailable Omega-3 DHA from Locally Available Ingredients for Prevention of Nutrition Related Mental Illnesses.(Taylor & Francis online) Charles, Christina; Swai, Hulda; Msagati, Titus; Chacha, MusaItem Development of Plant-Based Yoghurt Rich in Bioavailable Essential Nutrients and Bioactive Compounds from Ingredients Available in East Africa(Enviro Research Publishers.) Dusabe, Angelique; Chacha, Musa; Vianney, John Mary; Raymond, JofreyItem Effect of lactic acid fermentation, boiling and soaking on selected nutrients and health promoting components of mango seed kernels(International Journal of Biosciences) Runyogote, Joseph; Chacha, Musa; Ndabikunze, Bernadette; Raymond, JofreyItem Effect of Plant Powders on Survival, Oviposition and Progeny Development of Callosobruchus Maculatus for Protection of Leguminous Seeds during Post Harvest(International Journal of Science and Research) Zekeya, Never; Chacha, Musa; Shahada, FrancisItem Effects of Growth Conditions on the Forms of Xenorhabdus nematophila: A Symbiotic Bacterium of the Entomopathogenic Steinernema carpocapsae(Ingenta) Zhang, Fengqin; Makirita, Winisia E.; Wu, Lili; Yajie, Gou; Liu, Yong; Peng, Liuliang; Chacha, Musa; Mbega, Ernest; Li, Xiaolong; He, Nongyue; Liu, Tonghua
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