Browsing by Author "Mwingira, Felista"
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Item Comparison of detection methods to estimate asexual Plasmodium falciparum parasite prevalence and gametocyte carriage in a community survey in Tanzania(Springer Nature) Mwingira, Felista; Genton, Blaise; Kabanywanyi, Abdu-Noor M; Felger, IngridItem Effectiveness of intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy on placentalmalaria, maternal anaemia and birthweight in areas with highand low malaria transmission intensity in Tanzania(2014 John Wiley & Sons Ltd) Mosha, Dominic; Chilongola, Jaffu; Ndeserua, Rabi; Mwingira, Felista; Genton, BlaiseItem Malaria prevalence in asymptomatic and symptomatic children in Kiwangwa, Bagamoyo district, Tanzania(Springer Nature) Sumari, Deborah; Mwingira, Felista; Majige, Selemani; Mugittu, Kefas; Mugasa, Joseph; Gwakisa, PaulItem Malaria prevalence in asymptomatic and symptomatic children in Kiwangwa, Bagamoyo district, Tanzania(Malaria Journal, 2017) Sumari, Deborah; Mwingira, Felista; Selemani, Majige; Mugasa, Joseph; Mugittu, Kefas; Gwakisa, PaulMalaria prevalence continues to decline across sub-Saharan Africa as a result of various intervention strategies. However, the diseases still poses a public health concern in the region. While symptomatic malaria is recog- nized and treated, asymptomatic infections become increasingly important for interrupting transmission. A cross-sec- tional survey was conducted to assess malaria prevalence in symptomatic and asymptomatic children in Kiwangwa ward in Bagamoyo District in Tanzania. Methods: Four hundred school-aged children in Kiwanga ward were recruited in the study; 200 from Kiwangwa dispensary and 200 from nearby schools. Primary health parameters were examined and blood samples collected and examined for Plasmodium falciparum prevalence using rapid diagnostic test (RDT), light microscopy (LM) and reverse transcription quantitative PCR (RT-qPCR) targeting transcripts of A-type 18s rRNA of P. falciparum. Gametocytes were detected by LM and RT-qPCR targeting transcripts of gametocyte specific marker, Pfs25. Results: Overall P. falciparum prevalence was 73.3, 40.8 and 36.3% by RT-qPCR, RDT and LM in the study area, respec- tively (P < 0.001). As expected symptomatic children had a significantly higher prevalence of 89, 67.5 and 64.5% by qPCR, RDT and LM, compared to 57.5, 14 and 8% in the asymptomatic group, respectively. However, gametocyte prevalence in asymptomatic individuals was higher by both LM (2%) and qPCR (14%) than in symptomatic individuals LM (0.5%) and qPCR (3%). Conclusions: A substantial difference in prevalence of symptomatic and asymptomatic infections observed in Kiwangwa ward underpins the use of molecular tools in malaria surveillance aiming at estimating prevalence and transmission. Notably, the higher gametocytaemia observed in asymptomatic children indicates the reservoir infec- tions and points to the need for detection and treatment of both asymptomatic and symptomatic malaria.Item Plasmodium falciparum msp1 , msp2 and glurp allele frequency and diversity in sub-Saharan Africa(Malaria Journal) Mwingira, Felista; Nkwengulila, Gamba; Schoepflin, Sonja; Sumari, Deborah; Beck, Hans-Peter; Snounou, Georges; Felger, Ingrid; Olliaro, Piero; Mugittu, KefasItem Plasmodium falciparum msp1 , msp2 and glurp allele frequency and diversity in sub-Saharan Africa(Malaria Journal) Mwingira, Felista; Nkwengulila, Gamba; Schoepflin, Sonja; Sumari, Deborah; Beck, Hans-Peter; Snounou, Georges; Felger, Ingrid; Olliaro, Piero; Mugittu, KefasItem Plasmodium Falciparum Msp1, Msp2 And Glurp Allele Frequency and Diversity in Sub-Saharan Africa(BioMed Central) Mwingira, Felista; Nkwengulila, Gamba; Schoepflin, Sonja; Sumari, Deborah; Beck, Hans-Peter; Snounou, Georges; Felger, Ingrid; Olliaro, Piero; Mugittu, KefasItem Population Pharmacokinetics and Clinical Response for Artemether-Lumefantrine in Pregnant and Nonpregnant Women with Uncomplicated Plasmodium falciparum Malaria in Tanzania(American Society for Microbiology) Mosha, Dominic; Guidi, Monia; Mwingira, Felista; Abdulla, Salim; Mercier, Thomas; Decosterd, Laurent Arthur; Csajka, Chantal; Genton, BlaiseItem The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density(Nature Communications) Slater, Hannah; Ross, Amanda; Felger, Ingrid; Hofmann, Natalie; Robison, Leanne; cook, Jackie; Gonçalves, Bronner; Bjòrkman, Andes; Ouedraogo, Andre; Morris, Ulrika; Msellem, Mwinyi; Koepfli, Christian; Muller, Ivo; Tadesse, Fitsum; Gadisa, Endalamaw; Das, Simita; Domingo, Gonzalo; Kapulu, Melissa; Midega, Janet; Owusu-Agyei, Seth; Nabet, Cecile; Piarroux, Renaud; Duombo, Ogobara; Niare, Safiatou; koram, Kwadwo; Lucci, Nami; Udhayakumar, Venkatachalam; Mosha, Jackline; Tiono, Alfred; Chandramohan, Daniel; Gosling, Roly; Mwingira, Felista; Sauerwein, Robert; Paul, Richard; Riley, Eleanor; White, Nicholas; Nosten, Francois; Imwong, Mallika; Bousema, Teun; Drakeley, Chris; Okell, LucyItem Ultra-Sensitive Detection of Plasmodium falciparum by Amplification of Multi-Copy Subtelomeric Targets(PLOS) Hofmann, Natalie; Mwingira, Felista; Shekalaghe, Seif; Robison, Leanne; Muller, Ivo; Felger, Ingrid