A Dissertation submitted in partial fulfillment of the requirements of the Degree of Masters of Science in Procurement and Supply Chain Management of Mzumbe University 2019Public sectors need to establish a better way of improving the performance through reducing cost, minimizing the time of transaction, and quality of their activities. This study aimed to assess the factors affecting the implementation of e-procurement in Public sectors, OSHA being a case study that is also among public sectors in Tanzania. In general, the focus of this research study was to assess the factors affecting the implementation of e-procurement in Public sectors with the specific the objective of examining how legal framework, employee competency, technological infrastructure and security of data can affect the implementation of e-procurement in Public Sectors. Both reviews; theoretical examinations and empirical literature review were carried out to pinpoint the factors affecting the implementation of e-procurement in Public Sectors In this study a case study design was employed in order to provide material and realistic statistical data from the field concern. The target population was 150 staffs from OSHA and the sample size of this study were 50 respondents. None probability sampling technique was employed by the researcher to this study which was purposive sampling on which will be used to select only respondents who have knowledge of study topic so that to gate information. Questionnaires were prepared and distributed for data collection at OSHA. Quantitative statistics and multiple linear regression were used to determine factors affecting the topic under the study. However, data collected were presented by the use of tables and figures. The study found out that legal framework, employee competency, technological infrastructure and security of data are a challenge in e-procurement implementation in Public sectors; this study recommends that the organization needs to provide training to workers on the legal framework of procurement so as to make them competent, to have enough budget for running of an e-procurement system, technological infrastructure should be improved so that e-procurement implementation can be implemented easily and improve the accessibility of the data stored in electronic form as well as security the information for the users.