A Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Public Administration (MPA) of Mzumbe University.This study aimed at assessing the effectiveness of Prevention and Combating of Corruption Bureau (PCCB) in eradicating corruption in Tanzania. The study was guided by three specific objectives which generated research questions. The study employed exploratory design through facts generation from the new source. It was conducted in the headquarters of the organization and other subsidiary offices directed by the organization participants to access respondents. Information to fill the knowledge gap were gathered using interviews and questionnaires from the respondents selected as the sample size. Collected information using questionnaires were computed in SPSS data sheet to generate statistical measurements to present data. Descriptive statistics were used to present the results of all details collected using questionnaires. Data gathered through interviews were analyzed using content analysis and then presented using themes and narrations. Findings indicated that the entity is well capacitated legally and institutionally on eradicating corruption in Tanzania. Also, the study indicated several ways which show the effectiveness of the organization in eradicating corruption in Tanzania such as: the autonomy, legal mandate, organization and individual controls. In addition to that, several challenges bedeviling the organisation include: evidencing, witnessing, government interference, and information tampering. Therefore, the implication of the findings is that PCCB is an effective tool that entrusted with powers to fight against graft though notwithstanding the challenges it faces in executing its duties. The study recommends the government to invest heavily in supporting by pushing for its efficiency and effectiveness.