Background; Chronic Renal Failure is globally increasing due to increasing burden of non-communicable diseases like obesity, diabetes and hypertension. Therefore prevention and promotion of CKD is of strategic importance in our environment. Objective; To determine the prevalence, clinical characteristics and risk factors of chronic renal failure among patients admitted at KCMC medical department. Method; A prospective, cross-sectional analytical study was conducted in KCMC. A total of 387 systematically selected patients admitted in the medical department who fulfilled the criteria were examined for the presence of CKD. Results; The majority, 63% were above 50 years of age. Fifty four patients (14%) had chronic kidney disease. The presence of diabetes, hypertension, smoking and an age above 50 years were significantly associated with CKD. Clinical and Laboratory findings were consistent with advanced presentation at admission. This included high proportions of anaemia 30 (94%) among male CKD patients. Fourteen CKD patients (25.9%) died, those presenting with uremic encephalopathy were more likely to die. Conclusion and Recommensdations; Diabetes and Hypertension were found to rep-resent important risks for CKD. Hence strengthening prevention of these diseases is advocated. Most patients with CKD were admitted with advanced disease. Infor-mation on the reasons for late referral could be another research question. A signifi-cant number of CKD patients had anaemia, hence efforts to manage anaemia should be advocated.