Background: Community perception in biomedical research remains critical in Africa with many clients/individuals participating for different reasons, in most cases not related to the intended reasons for biomedical research. Objective: To explore perceived reasons for parents to volunteer their children to participation in biomedical research and the challenges encountered during mobilizing community to participate in biomedical research in Korogwe District, Tanzania. Methods: Focus group discussions with women of reproductive age and in-depth interviews with the community owned resource persons were used to explore the perceptions and challenges encountered from respondents. Results: Need for better health services, availability of qualified doctors, and better access to services provided at the research points were reported as main reasons why people participated in the research. According to the community owned resource persons, many of the reasons for non participation were linked to misconception of the malariometric survey; negative perception of rapid diagnostic test and its sensitivity, fear of knowing human immunodeficiency virus infection /acquired immune deficiency syndrome status and lack of trust on the information provided by the community owned resource persons. Challenges reported include low literacy among participants, time consumption in mobilization of community and difficulties in responding to many questions that were raised by participants particularly on why the community owned resource persons tested and treated malaria only. Conclusion: This study has shown that majority of community perceived positive about malariometric survey services provided. The availability of free health services was the major determinant factor of community participation in Malariometric surveys. Misconception about blood drawn for malaria test, such as taking blood for business purposes, fear of testing for HIV were mentioned by CORPs as recruitment challenge.