| dc.creator |
Liyoyo, Alphonce |
|
| dc.creator |
Semvua, Hadija |
|
| dc.creator |
Lekule, Isack |
|
| dc.creator |
Mpagama, Stellah |
|
| dc.date |
2015-10-28T07:43:25Z |
|
| dc.date |
2015-10-28T07:43:25Z |
|
| dc.date |
2015-08 |
|
| dc.date.accessioned |
2019-12-06T12:04:12Z |
|
| dc.date.available |
2019-12-06T12:04:12Z |
|
| dc.identifier |
http://hdl.handle.net/123456789/668 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/14898 |
|
| dc.description |
Background: Introduction of molecular diagnostic tools revolutionized the management of the multidrug resistance tuberculosis (MDR-TB). Strategies to optimize utilization are needed to reverse the current trend and exceed the achievements attained in TB control.
Objectives: To determine the effect of molecular diagnostics in referring patients for MDRTB treatment in terms of duration from diagnosis to start of treatment, and eventually treatment outcomes.
Methods: This was a cross sectional hospital based study conducted at Kibong’oto National Tuberculosis Hospital in Tanzania (KNTH). Data were collected from KNTH patients’ hospital charts, MDR-TB program cards and registers using a designed questionnaire. Collected data were reviewed from January 2013 to December 2013and entered into data base where they were analysed according to objectives
Results: A total of 95 MDRTB cases were referred for treatment in 2013 at KNTH. Eighty-four (80%) patients were analyzed. Seventy seven (91.7%) were diagnosed by molecular methods. Thirty six cases (43%) were HIV co-infected with 21 (60%) having CD4 count of less than 200cell/mm3. Sixty nine cases (82%) had history of previous TB treatment. The time from specimen collection to treatment initiation was reduced from 7 months by the conventional methods to 22 days by molecular methods. Sixty six cases (80%) were discharged after finishing intensive phase of treatment. Seventy three (90%) achieved culture convention and 67 (92%) converted within 2 months of treatment.
Conclusion: The findings consolidate evidence based strategies to optimize MDR-TB diagnosis using molecular diagnostics with the overall goal of halting MDR-TB transmission in the community.
Key words: Multi-drug Resistance Tuberculosis, molecular diagnostics, management,
Tanzania |
|
| dc.language |
en |
|
| dc.subject |
Research Subject Categories::MEDICINE |
|
| dc.title |
THE EFFECT OF MOLECULAR DIAGNOSTICS IN MANAGEMENT OF MULT DRUG RESISTANT TUBERCULOSIS IN TANZANIA |
|
| dc.type |
Thesis |
|