Background: Most of the countries with the lowest rates of contraceptive use; highest maternal, infant, and child mortality rates; and highest fertility rates are in Africa (WHO, 2010). Approximately 30% of all women use birth control, although over half of all African women would use birth control if it were available. There is evidence that increased use of family planning methods decreases maternal and infant mortality rates, improves quality of life for mothers, and stimulates economic development (WHO, 2010). The American Congress of Obstetricians and Gynecologists (ACOG) and WHO recommends that intrauterine devices (IUDs) and implants “should be considered as first-line choices for both nulliparous and parous adolescents,” due to their contraception effectiveness, high continuity rate, unlimited initiation time and higher fertility recovery (Hillard et al, 2012). However, these devices are not typically provided until a patient's six-week follow-up appointment, and 40 percent of patients do not return for those visits, despite often having resumed intercourse (Colwill, 2014). In low-income countries including, IUD use has been declining (Bertrand et al. 2014). This study will assess the postpartum contraception prevalence of IUD and associated factors among postpartum women attended at KCMC and will give platform for reducing maternal and neonatal morbidities mortalities hence contributing in achieving the MDGs number 4, 5 and 6. Study objective: To determine the predictors of post partum intrauterine device uptake among women delivering at Kilimanjaro Christian Medical Centre, Moshi. Methodology: The study design will be a cross-sectional analytical study. The study area will be KCMC hospital at admission labour ward and postnatal wards. Antenatal women will be enrolled and given counselling on postpartum IUD contraception during admission to antenatal general and postnatal wards. These women will include all pregnant women delivering between 1st September 2016 and 28th February 2017. Demographic, obstetrics, gynaecological and fertility characteristics will be extracted using standardised questionnaire. Those that will opt for IUD will be offered their contraceptive method of choice (IUD). The CuT 380A IUDs will be used. All clients who will have IUD inserted will be referred at their routine or nearby Reproductive and health clinic for follow-up. These data will be analysed by using SPSS version 22. The ethical clearance will be obtained from the Tumaini University College Research Ethical Committee.