Background: Perceiving the significance of knowing the factors which influence the morbidity and mortality in patients with obstructive jaundice is very important, this will better guide appropriate measures to reduce the burden and improve survival of the patients. Objective: To determine the etiology and assess the surgical managements and post-surgical outcomes of obstructive jaundice among patients admitted at KCMC referral hospital from 2013 to 2015. Methodology: A retrospective hospital based cross-sectional study was done to identify the etiologies, surgical managements and post-surgical outcomes of obstructive jaundice among patients admitted at KCMC referral hospital from 1st January 2013 to 31st December 2015. This study included only patients aged ≥15 years. There was a data extraction sheet for each patient which was used to record the social demographic data of the patient, etiology, treatment done and post treatment outcomes. Data was processed and analysed by using SPSS Version 20. Data entry was done daily at the field and was then cleaned and checked for completeness and consistency before analysis. Descriptive statistics (median, range, tables, figures and graphs) were used to summarize the data. Results: A total of 90 patients with obstructive jaundice treated in surgical one (S1) department were analyzed, from which 58 patients (64.40%) were males and 32 patients (35.60%) were females. Their age ranged from 20 to 93 years with a median age of 63 years. Malignant causes were the predominant cause of the disease affecting 70 patients (77.80%) with CA head of pancreas being the commonest cause, while the rest, 20 patients (22.20%) was due to benign causes and choledocholithiasis was the most predominant cause. A total of 63 patients (70%) had surgical operation. Mortality rate was 22.20%. Conclusion: Obstructive jaundice is common among males and the cause is mostly malignant with most of the patients presenting late to the hospital. To improve the prognosis of the patients, early diagnosis and treatments should be emphasized.