COSTECH Integrated Repository

Anti-Mycobacterial Activity on Middlebrook 7H10 Agar of Selected Congolese Medicinal Plants

Show simple item record

dc.creator Bongo, G.N
dc.creator Tuntufye, H.N
dc.creator Malakalinga, J
dc.creator Ngbolua, K
dc.creator Pambu, A.L
dc.creator Claudine, T
dc.creator Mbadiko, C.M
dc.creator Kazwa, R
dc.date 2019-10-29T05:35:23Z
dc.date 2019-10-29T05:35:23Z
dc.date 2018-12-06
dc.date.accessioned 2019-12-20T12:37:04Z
dc.date.available 2019-12-20T12:37:04Z
dc.identifier 2381-7690 (Print)
dc.identifier 2381-7704 (Online)
dc.identifier http://www.suaire.suanet.ac.tz:8080/xmlui/handle/123456789/2932
dc.identifier.uri http://hdl.handle.net/123456789/31488
dc.description Bioscience and Bioengineering' 2018; 4 (4): 68-77
dc.description In recent years, Tuberculosis (TB) has re-emerged as a serious public health problem worldwide. The disease spreads more easily in overcrowded settings and in conditions of malnutrition and poverty. The emergence of multidrug resistant and lengthy therapy reduces the patient compliance which comprises TB control strategies. In the current study, the leaves of Terminalia ivorensis, Carapa procera, Fagara macrophylla, Anacardium occidentale, Ficus spp. and Drepanoalpha® were extracted using petroleum ether, ethyl acetate and methanol in order to assess their anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium tuberculosis spp. on Middlebrook 7H10 agar using a qualitative approach where the activity was determined by the presence or the absence of growth on the plate. The phytochemical screening was used for the identification of the major groups of compounds found in the extracts. The methanolic extract displayed a good activity on both strains than the petroleum ether and ethyl acetate. The presence of alkaloids, flavonoids, tannins, saponins, anthocyanins, quinones known to be of medicinal importance points out a possible source for anti-mycobacterial agents to address the problem of multidrug resistance. The in vitro findings of this study provide a partial support for the use of these plants in the management of various infectious diseases as lead to drug discovery and should be reiterated and recommended for a clinical trial using an animal model.
dc.description BEBUC Scholarship System, (Bourse d’Excellence Bringmann aux Universites Congolaises), the Else-Kroener-Fresenius Stiftung, the Holger-Pohlmann-Foundation (Deutschland) and INTRA ACP Academic Mobility Scheme
dc.language en
dc.publisher American Institute of Science
dc.relation Bioscience and Bioengineering;4
dc.subject Tuberculosis
dc.subject Middlebrook 7H10 Agar
dc.subject Anti-mycobacterial Activity
dc.subject Phytochemical Screening
dc.subject Medicinal Plants
dc.title Anti-Mycobacterial Activity on Middlebrook 7H10 Agar of Selected Congolese Medicinal Plants
dc.type Article


Files in this item

Files Size Format View
Kazwala 2.pdf 323.4Kb application/pdf View/Open

This item appears in the following Collection(s)

Show simple item record

Search COSTECH


Advanced Search

Browse

My Account