This paper evaluates the capacity of higher learning institutions to tap business opportunities in the East African Community (EAC) following signing of the trade facilitation protocol in 2010, a move that opened doors for organizations to do business in the enlarged market. Although doors are opened for business, higher learning institutions in Tanzania including the College of Business Education (CBE) have been confined to the local market. This study examines the capacity of these institutions in tapping business opportunities in the EAC market. A case study research design was adapted and quantitative data collected using structured questionnaires. The study was guided by innovative theory “Creative Destruction” and Resource Based View (RBV). A sample of 32 respondents was randomly selected so as to avoid bias. Data were analyzed using tabular method and critical variables were used to draw the conclusion. The main findings indicate that the emerged opportunities are not tapped by Tanzanian Higher Learning Institutions (HLIs) as opposed to other universities in developed countries due to having some weaknesses that need to be addressed