The objective of this study was to examine the risks and challenges associated with e-payment systems in Tanzania and also to develop recommendations for mitigating them. The study used the theory of Technology Adoption Model (TAM) and employed descriptive research design. The study was conducted in Dodoma municipality whereby raw data were collected from 36 respondents using questionnaires as data collection instruments. Data were analyzed by using descriptive statistics whereby frequency of the variables are presented in tables showing the magnitude of occurrence in percentages; Pearson chi-square test was used to test the relationships between the variables to determine if there is any significant difference between them at 10% significance level. Findings indicates that majority of users of e-payment systems in Tanzania (53%) encountered loss in different levels ranging from 1- 5 Millions Tshs. Poor communication was reported the most challenging factor while interbank fund transfer was reported the most secure method in doing online transactions in Tanzania. The study also indicates that there is no significant difference between the challenges and the status of making e-payment transaction while on the other side findings indicates that there is a significant difference between risks of e-payment system and sex whereby the risk is more severe to males than females. Finally, the study provides conclusion and recommendations that could help to address the risks and challenges of e-payment systems in Tanzania.