There has been considerable interest and activities in clustering and the concomitant link to the regional development in recent times. The study wanted to help promoting of ICT usage in clusters for business process re-engineering within SIDO settings. This is due to challenges faced by SMEs clusters in performing business activities such as promoting their products outside their locality, using ICT in their businesses and gain other more benefits provided by the use of ICT technology. The study was conducted in Morogoro Municipal in Morogoro region with the main purpose of examining the extents to which SMEs clusters promote the usage of ICT within cluster environments. Precisely, the study sought to find out whether the use of ICT provides benefits and opportunities among the SMEs clusters, to assess the level of awareness on the usage of ICT in promoting business and its impact to the development of SMES clusters and to investigate the efficiency and effectiveness of the use of ICT tools to SMEs clusters in promoting business. About 88 SMEs dealing with clusters of (Metal work, Food processing, Clothes and Cereal flour) were involved in this study to understand the relationship between the use of ICT and business process re-engineering promotion among SMEs, the extent of SMEs clusters awareness of ICT usage in promoting their business and the extent of using it in business process re-engineering in improving the service and customer satisfaction. Statistical Package for Social Sciences (SPSS) version 20 was used to analyze the data collected.