Despite the vast and richness of antonymous pairs possessed in Bantu languages, very little effort has been put to investigate them, as compared to other European languages. The overall image from the current literature is negative- no single study has been cited upon it, in spite of being a robust sense relation in many natural human languages. This research, therefore, aimed at studying this sense relation using Nyakyusa, as one of the Bantu languages. The study used a qualitative research methodology to collect data from the field. The methods involved included: Interviews, lexical questionnaires, documentary review and Focus Group Discussions. A research was guided by a Conceptual Semantics framework which investigates how linguistic utterances are related to human cognition, distinguishes a single, universal meaning to a word .Conceptual Semantics is considered to be, not just a linguistic theory, but a theory of human cognition. Data obtained from the field was established into tabular pair-wise categories, which reflected the linguistics terms for types of antonyms. Results indicate categories of antonyms as Gradables, Complementarities, Reverses, Relationals and Directional antonyms. Further analysis was also done to examine the pairs formulated, on how one could easily apply them in different sentential constructions. A researcher is very hopeful, that this work could form a good base, upon which other researchers could build on, to investigate other sense relations in Bantu languages.