The aim of this study was to investigate the influence of job characteristics on employees’ job satisfaction at the College of Business Education, Mwanza Campus, taken as a case study. The job characteristics consisted of skill variety, task identity, task significance, autonomy, and job feedback. The job satisfaction variables studied were achievement, recognition, and responsibility, which were purposively chosen because of their recurrence in models for work motivation. The study sample involved 42 employees of CBE, Mwanza Campus, both academic and administrative staff. The study was approached quantitatively, and data were statistically analyzed in terms of frequencies and percentages. Questionnaire with 5-level Likert Scale was used as a research instrument to collect data. The findings indicated that all job characteristics have positive influence on job satisfaction through employees’ achievement, recognition, and responsibility, except skill variety that indicated low level of influence on responsibility. The general finding revealed that job feedback highly influences employees’ achievement, recognition, and responsibility than other job characteristics involved in the study. The general implication is that getting job feedback makes the employee able to assess his or her achievement of goals, which awakes in him or her sense of responsibility for job outcomes, which in turn may lead to recognition for the work well done. Consequently, job satisfaction, which is essential for job satisfaction is induced in the employee.