This study examines the applicability of the Principle of Universal Jurisdiction as a tool of International Criminal Justice and the challenges for Africa. The problem addressed by this study is the applicability of the principle of universal jurisdiction as a challenge for Africa in administration of international criminal justice in Africa. with the specific focus on Africa and international criminal project system, and looking on how issues of state sovereignty and immunity of state officials hinders the efforts of the African states to end impunities using the principle of universal jurisdiction as a tool. The study is governed by the main objective which is to find out whether there is an operational link between the national criminal jurisdiction and the universal jurisdiction in Africa in addressing international crimes and whether the international court use of the universal jurisdiction is on targeting African leaders as specific objectives. This study has found out that, the application of the principle of universal jurisdiction as a tool for international criminal justice in Africa is a challenge as encounters a number of challenges among being the state sovereignty and immunity of some state official who are accused of committing international crimes. The study found further that, there is no operational link between the universal jurisdiction and domestic criminal jurisdiction as the universal jurisdiction principle jeopardises the territorial jurisdiction which is more preferable in Africa. It was further submitted that the ICC does not target African leaders.