Trade unions have not played their role effectively on improving staff welfare at workplace in Tanzania and this has been contributed by various challenges they face within these organisations. This study focused on the following specific objectives, to explore workers perception regarding the significance of trade union, also the study kept a focus on determining the welfare amenities provided at Muhimbili National Hospital (MNH). This study, therefore, serves to identify the role of trade union especially the one at the Muhimbili National Hospital in influencing better staff welfare. In general this study has exposed the significance of improving staff welfare at workplaces, and the consequences of failing to bridge the gap between employees’ grievances and management responses through the forum of workers’ representatives, alias trade unions as the one responsible for that role. However this study also revealed the challenges that hinder proper functioning of the trade unions in influencing the improvement of staff welfare. The conclusion of the study saw that Trade Unions in Tanzania still have a very frail role in improving welfare of employees. It is necessary for trade unions to ensure that they improve the relations between them and the management of the organizations where their members are found, and Trade Union should fulfil their basic and primary role of promoting and protecting the interests of its members in all aspects including improved staff welfare.