The study concetrated on the „„Influence of Misungwi District Education Leadership upon Primary School Teacher In-service Training‟‟ and is more traced back since the introduction of Universal Primary Education (UPE) under Musoma declaration in 1974, where primary schools increased in number. With respect to the goal of achieving universal primary education as has been on the international agenda since the Universal Declaration of Human Rights affirmed, in 1948, that elementary education was to be made free and compulsory available for all children in all nations. The study covered the general objective which required to understand the influence of district education leaders upon primary school teacher in-service training. A total of 110 respondents were involved in the study also the study has witnessed the validity and reliability of some theories such as Instructional theory and Personal theory. The respondents were obtained through systematic random sampling, and purposive sampling. Interviews, questionnaire and documentary review were instruments used in data collection. The study used the qualitative and quantitative data analysis techniques, where by quantitative data were analysed using a Statistical Package for Social Science (SPSS) version 20. The researcher recommends that district education departments are required to support in-service training at all levels, upgrading teachers should be involved in district education plans, setting of in-service training courses on good coordination among teachers versus educational administration