The study aimed at making an evaluation on how the practice of clinical supervision led into improvement of teaching and learning in public secondary schools in Missenyi District.It employed mixed research approach as well as a convergent parallel research design. Eighty-seven (87) respondents (60 teachers, 4 heads of school, 6 School Quality Assurance officers,16 Ward Education officers and 1 District secondary education officer)were included.They were selected through purposive and simple random sampling techniques. Data were collected using open-ended questionnaires and closed ended interviews. Quantitative data were analysed using frequencies, percentages, tables and figures through SPSS software version 20 while qualitative information were analysed through coding, categories and themes. Four research objectives were used to analyse data based on the study.The findingsestablish that clinical supervision play a fundamental role in improving teaching and learning if well practiced in public secondary schools.It was revealed that supervisors’ and teachers’ commitment,accountability, transparency,good working environment, good governance policy and on-time feedback influenced teachers’ professional development and growth.The study recommended that the governmentshould ensure there is clear policies which guide better secondary school supervisionpractices to achieveimproved teaching and learning; school supervisors should ensure there is improvement of teaching and learning including improvement of mutual relationship, good environment for work, positive teachers’ perception toward supervision and goal oriented supervision, teachers to develop and grow professionally, realize their duties and commit in their performance when given mutual supervisor-supervisee relationship and conducive working conditions in schools to attain the set school goals and objectives.