Students’ perceptions play a significant role in their academic performances. This study assessed the influence of secondary school students’ perceptions on Mathematics subject in Tarime district-Tanzania. Specifically, the study sought to identify the kind of strategies which schools should adopt in order to cultivate in students’ positive attitudes towards Mathematics subject. The study utilized a mixed approach which adopts a cross sectional research design. The data were collected through questionnaire, unstructured interview and focus group discussion. Instrument for data collected were tested and were valid and reliable. The study used the sample size of 154 respondents which comprised teachers; continuing students and ex-students were involved. The data were analyzed through descriptive statistics and thematic analysis. In Descriptive statistics, the Statistical Package for Social Science (SPSS) software version21 was used to analyze data collected from questionnaires. Likewise, the data gathered through the focus group discussions and unstructured interviews were analyzed thematically. The findings from this study indicated that 56.7% students had a positive perception towards Mathematics. The study also found that despite their positive attitude towards mathematics still performed unsatisfactorily. The study further suggested that the number of mathematics teachers should be increased. The study recommended that educational stake holders should implement some initiative that will increase the number of mathematics teachers in public secondary schools.