The main purpose of the study was to examine on effectiveness of ICT integration on effective teaching and learning in public secondary schools found in Misungwi district.The study employed mixed research approach and the convergent parallel design for data collection. The study targeted a sample size of 100 respondents which comprised 64 students, 5 school heads, 30 secondary school teachers and 1district secondary education officer. Study employed simple random, stratified and purposive sampling to decide on respondents and the data collection tools were questionnaires, interview and observation. The study revealed that implementation of ICT has many extents on effective teaching and learning processand such as it enhances the accessibility of teaching and learning materials, improve teachers and students knowledge and skills and makes lesson more effective, makes student-centered and self-directed, makes and creative good teaching and learning environment and improve high thinking capacity for students and teachers. Furthermore the study revealed that ICT integration in public secondary schools faced varieties of challenges including lack ICTs equipment, lack of ICT infrastructure such computer rooms, insufficient funds, in adequate of ICT experts, poor internet service, inadequate of ICT training for teachers and lack of electricity in many public secondary schoolsin Misungwi. The study recommended that ICT infrastructures such as computers and other ICT resources should be adequately provided and secondary schools leaders should establish income generating projects to increase sources of funds and in-service training as well as special programs on ICT should be provided to teachers to boost their expertise and familiarity on the use of ICT and implications in teaching and learning.