The study assessed the influence of organizational factors teachers‟ turnover in private colleges with reference Mwanza in Tanzania. The objectives of the study were to establish how organizational change, training and economic factors influence employee turnover in private tertiary colleges. The theoretical framework of this study was derived from the Expectance theory and Herzberg two-factor theory. The study used a descriptive survey design. The target population of the study was 90 employees and a sample of 72 teachers was picked. This sample was picked using stratified sampling and simple random sampling. Questionnaires were used to collect data. Ten (10) employees were used for Pilot testing before the commencement of the study. Data analysis was done using Statistical Package for Social Sciences (SPSS). Descriptive statistics was computed and data was presented using tables. The study findings indicated that organizational change influence employee turnover. The organizational structure of private colleges should ensure that the institution has proper staff workload, set targets and the organization structure should have strong communication systems capable of creating awareness on information required by staff. The staff in private institutions should be well educated, motivated, stable and responsive; and be offered chances to attend refresher courses because opportunities for training and development are among the most important reasons why employees stay especially young and enthusiastic ones. Economic factors such as salary, allowances and any other sources of income, influence employee turnover. The staff in tertiary colleges should be provided with good working conditions which will make the staff motivated and increase staff retention. The staff promotion should be fair, done at the stipulated time and everybody be given equal opportunity. The generated information will help private college managers to be able to understand the determinants of staff turnover in these institutions. The study will help government departments in the Ministry of Education to come up with policies which will improve the performance and retention of staff in private institutions. The study will also help policy makers in planning for education systems for private institutions.