A Book chapter, Climate Variability and Change in Africa, Sustainable Development Goals Series, 115-136 pp.This study evaluates the impacts of climate change and an adaptation strategy on agricul- ture in the Wami River sub-basin in Tanzania. This study uses the Agricultural Model Improvement and Inter-comparison Project (AgMIP) framework that integrates climate, crops and economic models and data using a novel multi-model approach for impact assess- ment of agricultural systems under current and future conditions. This study uses five Global Circulation Models (GCMs) from the fifth phase of the Coupled Model Inter-comparison Project (CMIP5), two crop simulation models, and one economic impact assessment model. In this study, a representative agricultural path- ways (RAP) that characterises future condi- tions following ‘business-as-usual’ trends was developed and used to model future agricul- tural systems in the Wami River sub-basin. Results show that by mid-century, the maxi- mum and minimum temperatures will increase by 1.8–4.1 °C and 1.4–4.6 °C, respectively. Rainfall is predicted to be variable with some places projected to increase by 12%, while in other areas it is projected to decrease by 14– 28%. Maize yields under these conditions are projected to decrease by 5.3–40.7%. Results show that under current conditions, 50–60% of farm households are vulnerable to losses due to climate change. The impacts of climate change on poverty and per capita income are also projected to be negative. Under the current production system, poverty rates were pro- jected to increase by 0.8–15.3% and per-capita income to drop by 1.3–7.5%. Future socio-economic conditions and prices offset the negative impacts of climate change. Under future conditions, the proportion of households vulnerable to loss is estimated to range from 25 to 50%. Per-capita income and poverty rates are expected to improve under the future climate change conditions. Poverty rates would decrease between 1.9 and 11.2% and income per-capita would increase between 2.6 and 18.5%. The proposed future adaptation pack- age will further improve household liveli- hoods. This integrated assessment of climate change projections using the improved meth- ods and tools developed by AgMIP has con- tributed to a better understanding of climate change and adaptation impacts in a holistic manner.