Health care providers are a community’s trusted source of health information and can impact on health literacy. However, their effectiveness depends very much on how health care providers recognize and respond to patients’ information and communication needs. This article from a cross –sectional study discusses the influence of the community members’ interaction with health professionals (CMIWHP) on health literacy (HL) under One Health Approach in selected wards in Morogoro, Tanzania. It specifically:- (i) assessed HL of the people in the study area, (ii) assessed CMIWHP, and; (iii) assessed the association/linkages (nexus) between CMIWHP and HL levels. Data was collected using a structured questionnaire administered through a Computer Assisted Personal Interviewing (CAPI) electronic platform from 1440 respondents obtained through multistage sampling procedure, 80 focus group discussions’ participants and 16 key informant interviewees. Indexes of score were constructed to measure CMIWHP and HL respectively. A chi-square test of independence was used to establish the association/linkages (nexus) between CMIWHP and HL. IBM-SPSS v.20 analysed quantitative data while qualitative data were organized into themes on specific objectives to back up findings. The study revealed, about one third of the respondents (32.9%) with adequate HL, moderate HL (30.8%) and majority with inadequate HL (36.3%). The results further indicate that only 17.5% (95% CI:15.0 to 19.9) had high CMIWHP, 42.5% (95% CI:39.5 to 45.9) with medium CMIWHP and the majority 40.0% (95% CI:37.2 to 43.1) had low CMIWHP. Chi-square results indicate a significant association between CMIWHP and HL, χ(2)=168.593, p=.000, phi=.342 It is concluded that CMIWHP significantly associates/links to HL levels, but with a medium effect . It is recommended that effective interventions should be established to enable further health care providers recognition and responses to patients’ information and communication needs.