The evidences that climate change (CC) is a real situation have been established by different scholars and international organizations. However, much of the vast and burgeoning literature on CC has indicated spatial differences on the impacts, vulnerability, and adaptation among different communities. On that basis, various studies have grouped Eastern Africa as the most affected region by CC and has the weakest capacity to adapt or/and mitigate the dreadful conditions posed by CC. This chapter attempts to indicate the socioeconomic vulnerability in eastern Africa that has been coupled by climate impacts. In doing so, a wide range of studies reflecting the region has been reviewed. The results exhibit that there has been a cause-effect relationship between anthropogenic activities and climate impacts. Although both natural and anthropogenic factors cause climate change, the latter is more pronounced in local conditions. The level of deforestation and degradation in most eastern Africa is exceedingly high and this has subsequently increased the emission of the top green greenhouse gases (CO2, CH4, and N2O) into the atmosphere. Thus, the resolutions of various conference of parties on CC need to adhere by both developed and developing countries for the betterment of the planet.