A DISSERTATION SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF RURAL DEVELOPMENT OF SOKOINE UNIVERSITY OF AGRICULTURE. MOROGORO, TANZANIA.The study was conducted in Mbilikiri and Motukeri villages which are in the proximity of Ikorongo and Grumeti Game Reserves in Serengeti District. A cross-sectional household survey and tsetse field survey were conducted between March and April 2016. A simple random sampling method was used to obtain 108 respondents and 2448 tsetse flies were collected. Data from the household respondents were collected using a structured questionnaire, key informant interviews, and focus group discussions. Quantitative data were analyzed using descriptive statistics and Chi-square test. The findings show that, both males and females are knowledgeable about climate change and tsetse flies. The perception on the influence of climate change on tsetse flies density was high for both males (74.4%) and females (76.7%) and the level of education showed statistically significant difference p<0.05 on the communities perception. In determining tsetse flies population density, higher tsetse density was found along the rivers in game reserves, followed by the forest and bushes in the game reserves and cultivated areas. Men were found to be at a higher risk of being bitten by tsetse flies than women. The study therefore, concludes that, the perception of local communities on the influence of climate change on tsetse flies density was high, and that, the level of education contributed to such perception. Among others, the study recommended that, community-based interventions against tsetse should be promoted and carefully designed to reach out all communities, especially those surrounding or neighbouring tsetse fly habitats and the infested areas of Ikorongo and Grumeti Game Reserves