Contribution of microbiota to innate and acquired gut immunity during health and disease

Malago, J. J.

dc.creator	Malago, J. J.
dc.date	2018-06-17T10:00:58Z
dc.date	2018-06-17T10:00:58Z
dc.date	2014
dc.date.accessioned	2022-10-25T08:52:51Z
dc.date.available	2022-10-25T08:52:51Z
dc.identifier	978-1-63117-296-0
dc.identifier	https://www.suaire.sua.ac.tz/handle/123456789/2365
dc.identifier.uri	http://hdl.handle.net/123456789/93090
dc.description	Book
dc.description	The contribution of intestinal epithelium to the innate immune system includes detecting luminal microbes, transducing signals, and activating inflammatory mediator release by epithelial and other cells of the immune system like the antigen presenting cells. Microbial antigens are detected by cells of the innate immune system through their pattern recognition receptors (PRRs). The PRRs recognize microbe-associated molecular patterns and generate signals that activate transcription pathways like nuclear factor kappa B and mitogen activated protein kinases. This activation leads to production of inflammatory and growth mediators that drive the immune system to elicit tolerance or immune response designated at maintaining immune homeostasis. Key to this signaling is the gut microbiota. Intestinal epithelial cell sensing of optimally balanced microbiota favors immune homeostasis whereas sensing under disrupted microbiota impairs immune function and predisposes to disease. Understanding the PRR-microbiota signaling would be useful in designing therapeutics for various immune-mediated disorders caused by imbalances of microbiota.
dc.format	application/pdf
dc.language	en
dc.publisher	Nova Science Publishers, Inc
dc.subject	Immune system
dc.subject	Microbiota pattern
dc.subject	Intestinal immunity
dc.subject	Immune homeostasis
dc.title	Contribution of microbiota to innate and acquired gut immunity during health and disease
dc.title	Influence of microbiota to pattern recognition receptor signaling for intestinal immunity
dc.type	Book