| dc.creator |
Kasanga, C. J |
|
| dc.creator |
Wadsworth, J |
|
| dc.creator |
Mpelumbe-Ngeleja, C. A. R |
|
| dc.creator |
Sallu, R |
|
| dc.creator |
Kivaria, F |
|
| dc.creator |
Wambura, P. N |
|
| dc.creator |
Yongolo, M. G. S |
|
| dc.creator |
Rweyemamu, M. M |
|
| dc.creator |
Knowles, N. J |
|
| dc.creator |
King, D. P |
|
| dc.date |
2022-06-14T10:06:55Z |
|
| dc.date |
2022-06-14T10:06:55Z |
|
| dc.date |
2014-06-12 |
|
| dc.date.accessioned |
2022-10-25T08:53:00Z |
|
| dc.date.available |
2022-10-25T08:53:00Z |
|
| dc.identifier |
1865-1682 |
|
| dc.identifier |
https://www.suaire.sua.ac.tz/handle/123456789/4256 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/93240 |
|
| dc.description |
This paper describes the molecular characterization of foot-and-mouth disease
viruses (FMDV) recovered from outbreaks in Tanzania that occurred between
1967 and 2009. A total of 44 FMDV isolates, containing representatives of sero-
types O, A, SAT 1 and SAT 2 from 13 regions of Tanzania, were selected from the
FAO World Reference Laboratory for FMD (WRLFMD) virus collection. VP1
nucleotide sequences were determined for RT-PCR amplicons, and phylogenetic
reconstructions were determined by maximum likelihood and neighbour-joining
methods. These analyses showed that Tanzanian type O viruses fell into the EAST
AFRICA 2 (EA-2) topotype, type A viruses fell into the AFRICA topotype (geno-
type I), type SAT 1 viruses into topotype I and type SAT 2 viruses into topotype
IV. Taken together, these findings reveal that serotypes O, A, SAT 1 and SAT 2
that caused FMD outbreaks in Tanzania were genetically related to lineages and
topotypes occurring in the East African region. The close genetic relationship of
viruses in Tanzania to those from other countries suggests that animal move-
ments can contribute to virus dispersal in sub-Saharan Africa. This is the first
molecular description of viruses circulating in Tanzania and highlights the need
for further sampling of representative viruses from the region so as to elucidate
the complex epidemiology of FMD in Tanzania and sub-Saharan Africa. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Trans boundary and Emerging Disease |
|
| dc.subject |
Tanzania |
|
| dc.subject |
Foot-and-mouth disease virus |
|
| dc.subject |
Serotypes |
|
| dc.subject |
Genotypes/topotype |
|
| dc.subject |
Molecular epidemiology |
|
| dc.title |
Molecular characterization of foot-and-mouth disease viruses collected in Tanzania between 1967 and 2009 |
|
| dc.type |
Article |
|