Chemotherapeutic and chemo-prophylactic efficacy of Kelamedium® an isometamidium was evaluated in five medium dairy farms and two traditional herds with a number of animals above 6 months age being 275 and 100 respectively. The trial also involved 42 smallholder dairy herds with 316 animals. The animals were clinically examined for trypanosomosis signs then screened for haemoparasites using blood smears and micro-centrifugation methods. Positive animals on smears were classified as “cases” and were treated with a curative dose (1 mg/kg bodyweight) of Kelamidium® and monitored for parasitological recovery on days three, six and nine. A total of six “cases” were encountered and five which were treated with Kelamidium® showed parasitogical and clinical recovery by days 3 and 9 respectively, whereas one animal died. Smear negative animals were randomly assigned to two treatment groups; with one group receiving a prophylactic dose (0.5 mg/kg) of Kelamidium® and the controls being treated with the same dose of Samorin®. These animals were then monitored clinically and re-screened on days 60 and 90-post intervention for re-infections. Kelamidium® showed a prophylactic efficacy of 99.4% and this was comparable (p>0.05) to that of Samorin® (99.7%). These results thus show that Kelamidium® offers an alternative choice to Samorin®.Kela (Hoogstraten Laboratories Belgium)