Journal ArticleThe COVID-19 pandemic presents a potential threat to wildlife resources in Africa. In this review, using Tanzania as a case, we examine the impacts and risks that wildlife sectors in Africa are facing or are likely to face as a result of this pandemic.We recognize loss of revenues from tourism as a major impact that could negatively influence the management of wildlife species and habitats. Loss of tourism revenues reduces capacity of the conservation agencies to fund conservation operations and support the benefit sharing schemes. Furthermore, it undermines the efficacy of conservation to compete with alternative economic activities which are ecologically damaging. Increased unemployment and household poverty due to closure of businesses may exacerbate wildlife crime and unsustainable activities. Additionally, contributions from donor-funding organizations and development partners cannot be guaranteed as revenues may be diverted to support other sectors including health. In order to address and minimize the impacts and reduce the risks to the wildlife sector, the following policy measures are recommended: ensure adequate budget for conservation; develop a crisis management plan; reconsider protocols for conducting wildlife trade; develop a comprehensive tourism recovery plan; promote scientific studies focusing on zoonoses and adopt a One-Health Approach as a matter of urgency in dealing with COVID-19 and future pandemics.