Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?

BENNETT, KELLY; SHIJA, FORTUNATE; KADDUMUKASA, MARTHA; MISINZO, GERALD; DJOUAKA, ROUSSEAU; HARRIS, ANGELA; L U T W A M A, J U L I U S; W A L T O N, C A T H E R I N E

dc.creator	BENNETT, KELLY
dc.creator	SHIJA, FORTUNATE
dc.creator	KADDUMUKASA, MARTHA
dc.creator	MISINZO, GERALD
dc.creator	DJOUAKA, ROUSSEAU
dc.creator	HARRIS, ANGELA
dc.creator	L U T W A M A, J U L I U S
dc.creator	W A L T O N, C A T H E R I N E
dc.date	2021-11-22T06:10:22Z
dc.date	2021-11-22T06:10:22Z
dc.date	2016-06-22
dc.date.accessioned	2022-10-25T08:53:33Z
dc.date.available	2022-10-25T08:53:33Z
dc.identifier	Print: 0962-1083
dc.identifier	Electronic: 1365-294X
dc.identifier	https://www.suaire.sua.ac.tz/handle/123456789/3894
dc.identifier.uri	http://hdl.handle.net/123456789/93866
dc.description	Increasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future dis- ease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti’s adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population (s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, histori- cal human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analy- sis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.
dc.format	application/pdf
dc.language	en
dc.publisher	John Wiley & Sons Ltd.
dc.subject	approximate Bayesian computation
dc.subject	domestication,
dc.subject	forest fragmentation
dc.subject	invasive species
dc.subject	Pleistocene climatic change
dc.title	Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?
dc.type	Article