Over-expression of heat shock protein 90 reduces the severity of carbon tetrachloride hepatotoxicity in rats

Malago, J. J.

dc.creator	Malago, J. J.
dc.date	2018-06-18T06:39:09Z
dc.date	2018-06-18T06:39:09Z
dc.date	2018
dc.date.accessioned	2022-10-25T08:53:38Z
dc.date.available	2022-10-25T08:53:38Z
dc.identifier	2307-4531
dc.identifier	https://www.suaire.sua.ac.tz/handle/123456789/2373
dc.identifier.uri	http://hdl.handle.net/123456789/93963
dc.description	International Journal of Sciences: Basic and Applied Research (IJSBAR)
dc.description	Cellular response to stress leads to production of heat shock proteins (Hsps) that are protective against various perturbations including stress, infection and inflammation. The liver is a victim to many body disturbances including intoxications and systemic diseases. Stemming on the ability of Hsps to protect an array of perturbations in various body systems, it is justifiable to explore their protective potency to the rat model of carbon tetrachloride (CTC)-induced hepatic toxicity. The current study therefore aimed at testing whether prior induction of Hsp90 could protect the liver against CTC. Rats were exposed to zinc sulphate (ZS) to induce Hsp90 then CTC for 8, 24, 48 or 72 hr. At the end of treatment, rats were sacrificed, autopsied, liver samples taken and fixed in formalin and routinely processed. Sectioned tissues were stained with hematoxylin and eosin or anti-Hsp90 monoclonal antibodies to assess morphological changes and Hsp90 expression respectively. CTC induced damage to the liver that was reduced by ZS. The ZS-mediated reduction of CTC-induced hepatic damage matched with ZS-induced over-expression of Hsp90. It is concluded that over-expression of Hsp90 is beneficial against CTC-induced hepatotoxicity.
dc.format	application/pdf
dc.language	en
dc.publisher	International Journal of Sciences: Basic and Applied Research
dc.subject	Carbon tetrachloride
dc.subject	Zinc sulphate
dc.subject	Hsp90
dc.subject	Protection
dc.subject	Rats
dc.title	Over-expression of heat shock protein 90 reduces the severity of carbon tetrachloride hepatotoxicity in rats
dc.type	Article