Wetlands perform vital role in providing useful goods and services to mankind. Because of their importance, human beings interactions with the wetlands’ physical environment have caused some of them to be highly degraded. Due to characteristic nature of wetlands being a common pool resource (CPRs), most researchers claim their degradation to be a result of poor institutions governing the interactions. Wetlands in Tanzania are very useful especially, in areas where agriculture is most prevalent. High pressure to exploit fertile and moist land in those areas has caused wetlands to be highly degraded. This study focused on the rules and regulations governing the resources access from the wetlands using Kilombero Valley as a case study. The study used choice modelling to identify the determinants of the access patterns and their impacts on wetland sustainable management. The results showed that physical nature of resources and characteristics of the users such as location, income and education determine what type of access one chooses to accrue products and services from the wetlands. To ensure wetland sustainable management, the policy makers and conservationists should consider these factors in enacting rules and regulation which would govern human interactions in the wetlands. Payment for environmental services could be used to enhance such options.