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The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania

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dc.creator Munisi, David
dc.creator Buza, Joram
dc.creator Mpolya, Emanuel
dc.creator Teckla, Angelo
dc.creator Kinung’hi, Safari
dc.date 2019-05-21T10:41:17Z
dc.date 2019-05-21T10:41:17Z
dc.date 2017-09-28
dc.date.accessioned 2022-10-25T09:15:56Z
dc.date.available 2022-10-25T09:15:56Z
dc.identifier https://doi.org/10.1155/2017/7035025
dc.identifier http://dspace.nm-aist.ac.tz/handle/123456789/117
dc.identifier.uri http://hdl.handle.net/123456789/94708
dc.description Research Article published by BioMed Research International
dc.description Administeringmore than one treatmentmay increase Praziquantel cure and egg reduction rates, thereby hastening achievement of schistosomiasis transmission control. A total of 431 S. mansoni-infected schoolchildren were randomized to receive either a single or repeated 40mg/kg Praziquantel dose. Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing scale, and HemoCue, respectively. At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%) (𝑝 < 0.001).Theegg reduction rate was higher on repeated dose (97.54%) compared to single dose (87.27%) (𝑝 = 0.0062).Geometric mean egg intensity was lower among those on repeated dose (1.30 epg) compared to single dose (3.18 epg) (𝑝 = 0.036) but not at 5 (𝑝 > 0.05) and 8 (𝑝 > 0.05) months with no difference in reinfection rate. No difference in the prevalence of stunting was observed between the two treatment regimens (𝑝 > 0.05) at 8 months, but there was an increase in the prevalence of wasting among those on repeated dose (𝑝 < 0.001). There was an increase in the mean haemoglobin levels at 8 months with no difference between the two arms (𝑝 > 0.05). To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments alone may not be sufficient.This trial was registered with PACTR201601001416338.
dc.format application/pdf
dc.language en_US
dc.publisher BioMed Research International
dc.subject Research Subject Categories
dc.title The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania
dc.type Article


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