| dc.creator |
Labuschagne, P. W. |
|
| dc.creator |
Adami, R. |
|
| dc.creator |
Liparoti, S. |
|
| dc.creator |
Naidoo, S. |
|
| dc.creator |
Reverchon, E. |
|
| dc.creator |
Swai, Hulda |
|
| dc.date |
2019-10-16T06:35:05Z |
|
| dc.date |
2019-10-16T06:35:05Z |
|
| dc.date |
2014-11 |
|
| dc.date.accessioned |
2022-10-25T09:20:34Z |
|
| dc.date.available |
2022-10-25T09:20:34Z |
|
| dc.identifier |
https://doi.org/10.1016/j.supflu.2014.08.004 |
|
| dc.identifier |
http://dspace.nm-aist.ac.tz/handle/123456789/487 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/95057 |
|
| dc.description |
Research Article published by Elsevier Volume 95 |
|
| dc.description |
In this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the variation of PDLLA/RIF ratio on co-precipitate characteristics was mainly investigated. The precipitated particles were analyzed in terms of their morphological, thermodynamic and crystallographic properties. In addition, loading efficiency and in-vitro release studies were conducted. Spherical PDLLA/RIF nanoparticles with mean diameter ranging from 123 to 148 nm were prepared. Loading efficiency was greater than 100% resulting in RIF loadings of 28.8 to 50.5%. X-ray diffraction revealed that the encapsulated RIF is in an amorphous state, while NMR spectra indicated no structural modifications after the SAA process. In-vitro release studies showed an initial burst release of 80–87% of total RIF loaded, necessary to suppress the generation of resistance by the microorganism, followed by first-order sustained release between 0.4 and 0.8 mg/L RIF per day over a period of 17 days. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.subject |
Supercritical assisted atomization (SAA) |
|
| dc.subject |
Nano-encapsulation |
|
| dc.title |
Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique |
|
| dc.type |
Article |
|