This research article published by MDPI, 2021This study provides a detailed assessment of land cover (LC) changes on the water balance components on data constrained Kikafu-Weruweru-Karanga (KWK) watershed, using the integrated approaches of hydrologic modeling and partial least squares regression (PLSR). The soil and water assessment tool (SWAT) model was validated and used to simulate hydrologic responses of water balance components response to changes in LC in spatial and temporal scale. PLSR was further used to assess the influence of individual LC classes on hydrologic components. PLSR results revealed that expansion in cultivation land and built-up area are the main attributes in the changes in water yield, surface runoff, evapotranspiration (ET), and groundwater flow. The study findings suggest that improving the vegetation cover on the hillside and abandoned land area could help to reduce the direct surface runoff in the KWK watershed, thus, reducing flooding recurring in the area, and that with the ongoing expansion in agricultural land and built-up areas, there will be profound negative impacts in the water balance of the watershed in the near future (2030). This study provides a forecast of the future hydrological parameters in the study area based on changes in land cover if the current land cover changes go unattended. This study provides useful information for the advancement of our policies and practices essential for sustainable water management planning.