| dc.creator |
Omwoyo, Wesley |
|
| dc.creator |
Melariri, Paula |
|
| dc.creator |
Gathirwa, Jeremiah |
|
| dc.creator |
Oloo, Florence |
|
| dc.creator |
Mahanga, Geoffrey |
|
| dc.creator |
Kalombo, Lonji |
|
| dc.creator |
Ogutu, Bernhards |
|
| dc.creator |
Swai, Hulda |
|
| dc.date |
2019-10-16T09:00:19Z |
|
| dc.date |
2019-10-16T09:00:19Z |
|
| dc.date |
2016-04-01 |
|
| dc.date.accessioned |
2022-10-25T09:20:43Z |
|
| dc.date.available |
2022-10-25T09:20:43Z |
|
| dc.identifier |
26724538 |
|
| dc.identifier |
https://doi.org/10.1016/j.nano.2015.11.017 |
|
| dc.identifier |
http://dspace.nm-aist.ac.tz/handle/123456789/492 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/95186 |
|
| dc.description |
Research Article published by Elsevier Volume 12, Issue 3, April 2016 |
|
| dc.description |
Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA into solid lipid nanoparticles (SLNs) as a nanomedicine drug delivery system. DHA-SLNs were characterized for physical parameters and evaluated for in vitro and in vivo antimalarial efficacy. DHA-SLNs showed desirable particle characteristics including particle size (240.7 nm), particle surface charge (+ 17.0 mV), drug loadings (13.9 wt %), encapsulation efficacy (62.3%), polydispersity index (0.16) and a spherical appearance. Storage stability up to 90 days and sustained release of drug over 20 h was achieved. Enhanced in vitro (IC50 0.25 ng/ml) and in vivo (97.24% chemosuppression at 2 mg/kg/day) antimalarial activity was observed. Enhancement in efficacy was 24% when compared to free DHA. These encouraging results show potential of using the described formulation for DHA drug delivery for clinical application. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.subject |
Dihydroartemisinin |
|
| dc.subject |
Nanomedicine drug delivery |
|
| dc.subject |
Solid lipid nanoparticles |
|
| dc.title |
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles. |
|
| dc.type |
Article |
|