This research article published by Elsevier, 2019Mental health illness associated with poor nutrition is a serious public concern worldwide. The most at risk individuals are children and adolescents in the developing world. Deficiencies in omega-3 DHA fatty acids have long been recognized as a major contributing factor for mental health illnesses. Provision of products rich in omega-3 DHA could address this problem. But most commonly used products do not have preformed omega-3 DHA, making them less suitable for prevention of mental illnesses in resource-poor countries. The objective of this study was to provide a narration of the best alternative source of bioavailable omega-3 DHA for promotion of mental health in developing countries. This study identified microalgae as the best natural source of preformed omega-3 DHA over fish oil which has been reported to contain heavy metals, antibiotics and other contaminants that may pose a serious safety concerns to consumers. The study has further narrated future opportunities around microalgae in East Africa. One of the opportunities is development of a business model that could accelerate sustainable production and utilization of microalgae for improved nutrition and health in Eastern Africa.