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Neutralization of Interleukin-10 Significantly Enhances Gamma Interferon Expression in Peripheral Blood by Stimulation with Johnin Purified Protein Derivative and by Infection with Mycobacterium avium subsp. paratuberculosis in Experimentally Infected Cattle with Paratuberculosis

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dc.creator Buza, Joram
dc.creator Hikono, Hirokazu
dc.creator Mori, Yasuyuki
dc.creator Reiko, Nagata
dc.creator Hirayama, Sachiyo
dc.creator Bari, Abusaleh
dc.creator Geril, Aodon
dc.creator Shu, Yujing
dc.creator Tsuji, Noriko
dc.creator Momotani, Eiichi
dc.date 2019-10-07T12:49:17Z
dc.date 2019-10-07T12:49:17Z
dc.date 2014-04
dc.date.accessioned 2022-10-25T09:20:48Z
dc.date.available 2022-10-25T09:20:48Z
dc.identifier
dc.identifier http://dspace.nm-aist.ac.tz/handle/123456789/461
dc.identifier.uri http://hdl.handle.net/123456789/95251
dc.description Research Article published American Society for Microbiology. All Rights Reserved Vol. 72, No. 4
dc.description Monoclonal antibody neutralization of interleukin-10 (IL-10) increased Johnin purified protein derivativeinduced whole-blood gamma interferon (IFN- ) secretion 23-fold and also increased IFN- secretion ninefold following in vitro Mycobacterium avium subsp. paratuberculosis infection of peripheral blood mononuclear cells. These results demonstrate the suppressive effect of IL-10 on immune responses to M. avium subsp. paratuberculosis infection in cattle.
dc.format application/pdf
dc.language en
dc.publisher American Society for Microbiology
dc.subject Research Subject Categories::NATURAL SCIENCES
dc.title Neutralization of Interleukin-10 Significantly Enhances Gamma Interferon Expression in Peripheral Blood by Stimulation with Johnin Purified Protein Derivative and by Infection with Mycobacterium avium subsp. paratuberculosis in Experimentally Infected Cattle with Paratuberculosis
dc.type Article


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