This paper presents analysis of the impacts of climate change to the livelihoods of people and the importance of Integrated Water Resources Management approach as climate change adaptation strategies for the sustainable development, allocation and monitoring of water resource use in the context of social, economic and environmental objectives. The analysis was based on the study which was conducted in the Great Ruaha River Catchment. Both quantitative and qualitative methods were used for data collection and analysis. The analysis shows that, climate variability leads to changes in the quantity, timing, intensity and duration of rainfall contributing to water stress in many areas and making people more vulnerable. The analysis also shows that, water-related adaptation measures to climate change can be provided with the Integrated Water Resource Management (IWRM) for efficient, equitable and sustainable development and management of water resources and water demands.