| dc.creator |
Lyantagaye, Sylvester L. |
|
| dc.date |
2016-05-05T14:11:35Z |
|
| dc.date |
2016-05-05T14:11:35Z |
|
| dc.date |
2013 |
|
| dc.date.accessioned |
2018-03-27T08:59:56Z |
|
| dc.date.available |
2018-03-27T08:59:56Z |
|
| dc.identifier |
Lyantagaye, S.L., 2013. Methyl-α-D-glucopyranoside from Tulbaghia violacea extract induces apoptosis in vitro in cancer cells. Bangladesh Journal of Pharmacology, 8(2), pp.93-101. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/1843 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/1843 |
|
| dc.description |
Pro-apoptotic activity of Tulbghia violacea extracts was evaluated in order to
understand the mechanisms of action that might be related to its traditional
use as anticancer medicine. Apoptosis-guided purification was used to isolate
active compound whose chemical structure was solved by using spectroscopic,
microanalysis and X-ray crystallography techniques. T. violacea extract
kills Chinese hamster ovary cells, MCF7, and HeLa cells through the induction
of apoptosis Methyl--D-glucopyranoside was identified as one of the main
pro-apoptotic compounds present in T. violacea extract. This is the first time
ever demonstration that T. violacea contains methyl -D-glucopyranoside,
which selectively kills cancer cells through apoptosis mechanisms. |
|
| dc.language |
en |
|
| dc.subject |
Apoptosis |
|
| dc.subject |
Anti-cancer |
|
| dc.subject |
Methyl-α-D-glucopyranoside |
|
| dc.subject |
Tulbaghia violacea |
|
| dc.title |
Methyl Dglucopyranoside from Tulbghia violacea α Extract Induces Apoptosis in Vitro in Cancer Cells |
|
| dc.type |
Journal Article, Peer Reviewed |
|