COSTECH Integrated Repository

Bio-recognition Ability of Polysaccharides as Piezo Quartz Biosensors

Show simple item record

dc.creator Kalmykova, E. N.
dc.creator Mgina, Clarence A.
dc.date 2016-06-15T20:52:32Z
dc.date 2016-06-15T20:52:32Z
dc.date 2012
dc.date.accessioned 2018-03-27T08:54:28Z
dc.date.available 2018-03-27T08:54:28Z
dc.identifier Kalmykova, E.N. and Mgina, C.A., 2012. Biorecognition Ability of Polysaccharides as Piezo Quartz Biosensors. Tanzania Journal of Science, 38(3), pp.209-220.
dc.identifier http://hdl.handle.net/20.500.11810/2472
dc.identifier.uri http://hdl.handle.net/20.500.11810/2472
dc.description Piezoquartz biosensors (PQB) which are analytical devices for recognition of biochemical interactions have recently attracted increasing interest from different researchers such as analysts, immune-chemists, medical doctors, environmentalists, etc. This is due to the advantages of PQB for having high detection sensitivity (at ng and mg level depending on the mass of sorbates or micro-organisms) and the ability to monitor biochemical reactions in turbid or highly coloured liquids (including in biological fluids) in real time. The use of additional markers and preliminary sample preparation are not required in this biorecognition process. This paper reports on the principle of the PQB and the design units to perform analysis in static and dynamic conditions using different types of biomolecules (immunoglobulins, DNA, lipopolysaccharides, glycoconjugates, hapten-protein conjugates and polysaccharides). Research results performed at the Department of Chemistry, Lipetsk State Technical University (Russia) and School of Physics, College of Natural Sciences, UDOM (Tanzania) are presented. The report aims to review various examples of use of carbohydrate molecules and glycoconjugates in the design of the PQB. These examples include the following: use of sulphated polysaccharides to increase the strength of the sensor’s bio-laye;, use of glycolipids such as O-antigens of bacteria (Yersinia enterocolitica) with different chemical structures in the development of immunosensors for the determination of specific immunoglobulins at 3-100 mg/ml levels in serum; and the use of polysaccharide hydrogels of the first chemical structure (hyaluronic acid, zosteran and neutral and acidic polysaccharide fractions isolated from water hyacinth Eichhornia crassipes) in studying their effectiveness in Pb2 + ions sorption.
dc.language en
dc.subject Quartz crystal microbalance
dc.subject Piezoquartz biosensors (PQB)
dc.subject Bioreceptor molecules
dc.subject Polysaccharide hydro gel
dc.subject Liquid media
dc.subject “Dip and dry”
dc.subject Flow injection analysis (FIA)
dc.subject Adsorption
dc.subject heavy metals
dc.title Bio-recognition Ability of Polysaccharides as Piezo Quartz Biosensors
dc.type Journal Article, Peer Reviewed


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search COSTECH


Advanced Search

Browse

My Account