The paper presents a review on the biomedical potentials of less common natural products recently isolated from some rare plant species indigenous to Tanzania. The conservation status of the plant species under review is also discussed. innamoyltetraketide derivatives, pseudo-nucleoside and aristolactams from Toussaintia orientalis (Annonaceae); heptenolides from Cleistochlamys kirkii, (Annonaceae); acetogenins, cyclitols and meroditerpenoid from Artabotrys species (Annonaceae); geranylbenzoquinonoids from Lettowianthus stellatus (Annonaceae); furanoditerpenoids from Stuhlmania moavi (Caesalpiniaceae); nor-halimanoid and ent-clerodanoid diterpenes, chlorobenzenoid, and other metabolites from Tessmannia species (Caesalpiniaceae) are some of those covered in this review