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New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species

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dc.creator Nyandoro, Stephen S.
dc.creator Joseph, Cosam C.
dc.creator Nkunya, Mayunga H. H.
dc.creator Hosea, Ken M.
dc.date 2016-06-26T17:08:48Z
dc.date 2016-06-26T17:08:48Z
dc.date 2012-09
dc.date.accessioned 2018-03-27T08:54:42Z
dc.date.available 2018-03-27T08:54:42Z
dc.identifier Nyandoro, S., Joseph, C., Nkunya, M., & Hosea, K. (2013). New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species. Natural Product Research, 27(16), 1450-1458. http://dx.doi.org/10.1080/14786419.2012.725397
dc.identifier 1478-6419
dc.identifier 1478-6427
dc.identifier http://hdl.handle.net/20.500.11810/2671
dc.identifier 10.1080/14786419.2012.725397
dc.identifier.uri http://hdl.handle.net/20.500.11810/2671
dc.description Full text can be accessed at the following link http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.725397?journalCode=gnpl20
dc.description Azabicycloheptenoylditerpene 1-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)-2-azabicyclo[2.2.1]hept-5-en-3-one (artamodamide, 1), diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one (artamenone, 2) and N-methoxy-5-oxoaporphinoid (artamonteirine, 3) were isolated as new metabolites from Artabotrys modestus Diels ssp macranthus Verdc. and Artabotrys monteiroae Oliv. (Annonaceae), together with several known compounds. Structures of the isolated compounds were established based on analysis of their spectroscopic data. Some of the compounds exhibited antimicrobial activity (minimum inhibitory concentration values between 2.5 and 20 µg mL−1) and varying levels of mosquito larvicidal potency. These results further indicate the versatility of the family Annonaceae in accumulating bioactive natural products with diverse chemical structures and wide spectra of biological activities, and hence suggesting the need to conserve Annonaceae species that are potentially vulnerable to extinction.
dc.language en
dc.publisher Taylor & Francis
dc.subject Annonaceae
dc.subject Artabotrys modestus
dc.subject Artabotrys monteiroae
dc.subject Azabicycloheptenoylditerpene
dc.subject diphenylpentanoid
dc.subject N-methoxy-5-oxoaporphinoid
dc.subject Antimicrobial
dc.subject Larvicidal
dc.title New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species
dc.type Journal Article, Peer Reviewed


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