| dc.creator |
Nyandoro, Stephen S. |
|
| dc.creator |
Ndanu, Joseph |
|
| dc.creator |
Munissi, Joan J. E. |
|
| dc.creator |
Gruhonjic, Amra |
|
| dc.creator |
Fitzpatrick, Paul A. |
|
| dc.creator |
Landberg, Göran |
|
| dc.creator |
Lu, Yu |
|
| dc.creator |
Wang, Bin |
|
| dc.creator |
Pan, Fangfang |
|
| dc.creator |
Rissanen, Kari |
|
| dc.creator |
Erdélyi, Máté |
|
| dc.date |
2016-06-26T17:09:03Z |
|
| dc.date |
2016-06-26T17:09:03Z |
|
| dc.date |
2015-07 |
|
| dc.identifier |
Nyandoro, S., Ndanu, J., Munissi, J., Gruhonjic, A., Fitzpatrick, P., & Landberg, G. et al. (2015). N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. J. Nat. Prod., 78(8), 2045-2050. http://dx.doi.org/10.1021/acs.jnatprod.5b00356 |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2677 |
|
| dc.identifier |
10.1021/acs.jnatprod.5b00356 |
|
| dc.identifier |
http://dx.doi.org/10.1021/acs.jnatprod.5b00356 |
|
| dc.description |
Seven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3-107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3-105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line. |
|
| dc.language |
en |
|
| dc.publisher |
PubMed |
|
| dc.subject |
N -Cinnamoyltetraketide |
|
| dc.subject |
Toussaintia orientalis |
|
| dc.title |
N -Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis |
|
| dc.type |
Journal Article, Peer Reviewed |
|