| dc.creator |
Aronsson, Per |
|
| dc.creator |
Munissi, Joan J. E. |
|
| dc.creator |
Gruhonjic, Amra |
|
| dc.creator |
Fitzpatrick, Paul A. |
|
| dc.creator |
Landberg, Göran |
|
| dc.creator |
Nyandoro, Stephen S. |
|
| dc.creator |
Erdélyi, Máté |
|
| dc.date |
2016-06-26T17:09:05Z |
|
| dc.date |
2016-06-26T17:09:05Z |
|
| dc.date |
2016-01-15 |
|
| dc.date.accessioned |
2018-03-27T08:54:36Z |
|
| dc.date.available |
2018-03-27T08:54:36Z |
|
| dc.identifier |
Aronsson, P., Munissi, J., Gruhonjic, A., Fitzpatrick, P., Landberg, G., Nyandoro, S., & Erdelyi, M. (2016). Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis. Diseases, 4(1), 3. http://dx.doi.org/10.3390/diseases4010003 |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2678 |
|
| dc.identifier |
10.3390/diseases4010003 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2678 |
|
| dc.description |
As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3′-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520–82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1–5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed. |
|
| dc.language |
en |
|
| dc.publisher |
MDPI |
|
| dc.subject |
Diospyros shimbaensis |
|
| dc.subject |
Ebenaceae |
|
| dc.subject |
Tetralones |
|
| dc.subject |
Naphthoquinoes |
|
| dc.subject |
Radical scavenging |
|
| dc.subject |
Cytotoxicity |
|
| dc.subject |
MDA-MB-231 |
|
| dc.subject |
DPPH |
|
| dc.title |
Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis |
|
| dc.type |
Journal Article, Peer Reviewed |
|