| dc.creator |
Mlimbila, Jane |
|
| dc.creator |
Muruke, Masoud H. |
|
| dc.creator |
Hosea, Ken M. |
|
| dc.date |
2016-06-26T17:12:39Z |
|
| dc.date |
2016-06-26T17:12:39Z |
|
| dc.date |
2014-01 |
|
| dc.date.accessioned |
2018-03-27T09:00:35Z |
|
| dc.date.available |
2018-03-27T09:00:35Z |
|
| dc.identifier |
Mlimbila, J.S. and Hosea, M.H.M.K.M., Bioactivity of crude extracts of Ascomycetes isolated from Tanzanian traditionally fermented milk, Mtindi. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2712 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2712 |
|
| dc.description |
In an attempt to find potential functional foods in Tanzania, a study was conducted to assess bioactivity of 18
ethyl acetate extracts from nine (9) Ascomycetes strains. Namely; Candida tropicalis, C. pararugosa,
Clavispora lusitaniae, Issatchenkia orientalis, Pichia kudriavzevii, Pichia guilliermondii, Galactomyces
geotricum, Debaryomyces hansenii and Yarrowia lipolytica isolated from traditional fermented milk “mtindi”.
Lethality test of the extracts was determined using Artemia salina naupalii in a Brine Shrimp Test (BST). The
lethal concentration (LC50) obtained ranged from 89.7µg/ml to over 1000 µg/ml. Bioactivity results showed that,
one of the 18 extracts had exhibited a strong antibacterial activity against Staphylococcus aureus, Pseudomonas
aureginosa and Vibrio cholera having minimum inhibitory concentration (MIC) values of 0.1653mg/ml on each
account. More than 40% of extracts exhibited strong to moderate antifungal activity against Cryptococcus
neoformans (MIC 0.16 mg/ml – 1.25 mg/ml). In conclusion, these results suggest that yeasts found in traditional
fermented milk have potential biological activity that could be used for treatment of some diarrhoeal and fungal
infections and possibly tuberculosis. |
|
| dc.language |
en |
|
| dc.subject |
Yeasts |
|
| dc.subject |
Brine Shrimp Test |
|
| dc.subject |
Antimicrobial Activity |
|
| dc.subject |
Traditional Fermented milk |
|
| dc.title |
Bioactivity of Crude Extracts of Ascomycetes Isolated from Tanzanian Traditionally Fermented Milk, Mtindi |
|
| dc.type |
Journal Article, Peer Reviewed |
|