| dc.creator |
Bringmann, Gerhard |
|
| dc.creator |
Dreyer, Michael |
|
| dc.creator |
Faber, Johan H. |
|
| dc.creator |
Dalsgaard, Petur W. |
|
| dc.creator |
Staerk, Dan |
|
| dc.creator |
Jaroszewski, Jerzy W. |
|
| dc.creator |
Ndangalasi, Henry J. |
|
| dc.creator |
Mbago, Frank M. |
|
| dc.creator |
Brun, Reto |
|
| dc.creator |
Reichert, Matthias |
|
| dc.creator |
Maksimenka, Katja |
|
| dc.creator |
Christensen, Søren B. |
|
| dc.date |
2016-07-08T12:00:52Z |
|
| dc.date |
2016-07-08T12:00:52Z |
|
| dc.date |
2003-09 |
|
| dc.date.accessioned |
2018-03-27T08:55:37Z |
|
| dc.date.available |
2018-03-27T08:55:37Z |
|
| dc.identifier |
Bringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M. and Maksimenka, K., 2003. Ancistrotanzanine A, the First 5, 3'-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5, 8'-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis#, 1. Journal of natural products, 66(9), pp.1159-1165. |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/2877 |
|
| dc.identifier |
10.1021/np030077b · Source: PubMed |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/2877 |
|
| dc.description |
Full text can be accessed at
http://pubs.acs.org/doi/abs/10.1021/np030077b |
|
| dc.description |
The first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines A (5) and B (6), and the known compound ancistrotectoriline A (7). Ancistrotazanine A (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. The structures of the compounds were determined by spectroscopic, chemical, and chiroptical methods. Compounds 5 and 6 showed good activities against the pathogens of leishmaniasis and Chagas' disease, Leishmania donovani and Trypanosoma cruzi, while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites. |
|
| dc.language |
en |
|
| dc.title |
Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1 |
|
| dc.type |
Journal Article |
|