This paper describes a proposed conceptual framework for integrating e-Health records for health research institutions. The framework is based on a cross-sectional study at Ifakara Health Institute in Tanzania. It is developed by identifying both social and technical aspects associated with intra-organization data integration and sharing. The two major questions answered in this research are: i) what are the principal socio-technical factors in a value chain of intra-organization data integration? and ii) what is the intensity and strength of these factors in influencing the effectiveness of health data integration and sharing between and across a network of collaborators? The specific objective of the study focuses on the impact of socio-technical factors on intra-organization data integration and sharing. Technical and social factors were analyzed as service requirements to enhance data integration in health research institutions. The significance of each domain in respect to data integration was identified. Finally, a conceptual framework was proposed to address the gap in the process of intra-organization data integration.