Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1

Bringmann, Gerhard; Dreyer, Michael; Faber, Johan H.; Dalsgaard, Petur W.; Staerk, Dan; Jaroszewski, Jerzy  W.; Ndangalasi, Henry J.; Mbago, Frank M.; Brun, Reto; Reichert, Matthias; Maksimenka, Katja; Christensen, Søren B.

dc.creator	Bringmann, Gerhard
dc.creator	Dreyer, Michael
dc.creator	Faber, Johan H.
dc.creator	Dalsgaard, Petur W.
dc.creator	Staerk, Dan
dc.creator	Jaroszewski, Jerzy W.
dc.creator	Ndangalasi, Henry J.
dc.creator	Mbago, Frank M.
dc.creator	Brun, Reto
dc.creator	Reichert, Matthias
dc.creator	Maksimenka, Katja
dc.creator	Christensen, Søren B.
dc.date	2016-07-08T12:17:32Z
dc.date	2016-07-08T12:17:32Z
dc.date	2003-10
dc.identifier	Bringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M. and Maksimenka, K., 2003. Ancistrotanzanine A, the First 5, 3'-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5, 8'-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis#, 1. Journal of natural products, 66(9), pp.1159-1165.
dc.identifier	http://hdl.handle.net/20.500.11810/2901
dc.identifier	10.1021/np030077b · Source: PubMed
dc.description	Full text can be accessed at http://pubs.acs.org/doi/abs/10.1021/np030077b
dc.description	The first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines A (5) and B (6), and the known compound ancistrotectoriline A (7). Ancistrotazanine A (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. The structures of the compounds were determined by spectroscopic, chemical, and chiroptical methods. Compounds 5 and 6 showed good activities against the pathogens of leishmaniasis and Chagas' disease, Leishmania donovani and Trypanosoma cruzi, while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites.
dc.language	en
dc.title	Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1
dc.type	Journal Article